News: Cancer Research

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Grant bolsters pancreatic cancer drug discovery

Thursday, January 29th, 2015

The Lustgarten Foundation has awarded a $1.5 million Research Investigator Grant to Stephen Fesik, Ph.D., professor of Biochemistry, Pharmacology and Chemistry, for research designed to discover new drugs for the treatment of pancreatic cancer. This is Fesik’s second three-year award from the Lustgarten Foundation in support of his research targeting K-Ras, a protein mutated in […]

Yoga therapy for cancer patients studied

Thursday, January 29th, 2015

Cancer is bad enough. But cancer patients who receive surgery, radiation and chemotherapy may suffer from side effects that run from irritating to crippling — problems that are postural, musculoskeletal and respiratory, along with lowered self-esteem. Many suffer from lymphedema, swelling caused by retained fluid in a compromised lymphatic system. One answer may be the […]

Data mining reveals cancer-driving genes

Thursday, January 22nd, 2015

Prospecting for genes that might be implicated in cancer, a Vanderbilt University Medical Center research team has struck pay dirt. Zhongming Zhao, Ph.D., Peilin Jia, Ph.D., and colleagues use novel computational methods to sift through online repositories of molecular data gathered by cancer researchers worldwide. These results, and further analyses planned by the team, can […]

Enzyme affects tumor metastasis

Thursday, January 8th, 2015

Breast cancer remains the most common type of cancer in females, with survival rates decreasing sharply for those with distant metastases. MMP2, a type of enzyme that degrades the extracellular matrix, has previously been implicated in the development of distant tumor metastases, but without a clearly defined role. In the Journal of Pathology, Barbara Fingleton, […]

Combo therapy may help fight melanoma

Thursday, January 8th, 2015

Two therapies already in clinical development as single agents may work in combination to treat many subtypes of melanoma, a recent study suggests.

Potential Prostate Cancer Blood Test

Tuesday, January 6th, 2015

Vanderbilt University researcher William Mitchell, M.D., Ph.D., and colleagues in Germany and Canada have demonstrated a method for detecting “cell-free” tumor DNA in the bloodstream.

Gene linked to breast cancer therapy response

Friday, November 21st, 2014

A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy. The study was published online in the Journal of Clinical Investigation. Luis Schwarz, M.D., and Emily Fox, Ph.D., served as co-first authors of the study, led by senior author Carlos […]

More breast cancer patients choose mastectomy

Friday, November 21st, 2014

Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows.

New insight on oral cancer culprits

Wednesday, November 12th, 2014

Oral squamous cell carcinoma (OSCC) treatments have been slow to advance despite the aggressive nature of these tumors that commonly metastasize. Models for the development of improved OSCC therapeutics have also been scarce. Thomas Andl, Ph.D., Claudia Andl, Ph.D., and colleagues previously observed coordinated loss of connective molecules (E-cadherin) and growth factor (TGFbeta) signaling in […]

Bone Cancer Image Featured in Contest

Tuesday, November 11th, 2014

An image by Dylan Burnette, Ph.D., an assistant professor of Cell and Developmental Biology and Vanderbilt-Ingram Cancer Center member, was chosen as a winning entry in the 2014 Nikon Small World Photomicrography Competition. Burnette’s image shows an osteosarcoma (bone cancer) cell at 8000X magnification.