A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy. The study was published online in the Journal of Clinical Investigation. Luis Schwarz, M.D., and Emily Fox, Ph.D., served as co-first authors of the study, led by senior author Carlos […]
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Far more breast cancer patients are choosing to undergo mastectomy, including removal of both breasts, instead of choosing breast conservation surgery even when they have early stage disease that is confined to one breast, a Vanderbilt study shows.
Oral squamous cell carcinoma (OSCC) treatments have been slow to advance despite the aggressive nature of these tumors that commonly metastasize. Models for the development of improved OSCC therapeutics have also been scarce. Thomas Andl, Ph.D., Claudia Andl, Ph.D., and colleagues previously observed coordinated loss of connective molecules (E-cadherin) and growth factor (TGFbeta) signaling in […]
An image by Dylan Burnette, Ph.D., an assistant professor of Cell and Developmental Biology and Vanderbilt-Ingram Cancer Center member, was chosen as a winning entry in the 2014 Nikon Small World Photomicrography Competition. Burnette’s image shows an osteosarcoma (bone cancer) cell at 8000X magnification.
Somatic mutations, which can occur in any cell except sperm or egg, are not inheritable. Several recent studies have demonstrated that disease-causing mutations commonly alter protein folding, protein stability and protein-protein interactions. It has been difficult, however, to determine which somatic mutations identified in tumor samples “drive” the cancer development and which are just “along […]
Melanoma, the most lethal form of skin cancer, spreads aggressively and is often resistant to therapy. Melanoma tumor formation is driven in part by nuclear factor-kappa B (NF-kappaB)-mediated gene transcription, and loss of NF-kappaB activity can block melanoma tumor formation. However, NF-kappaB also plays a crucial role in immune cells. In an October online edition […]
A new study explaining the cellular activity that leads to breast tumor metastasis among women who have recently given birth may offer new treatment direction for postpartum breast cancer.
Findings suggest a combination of therapies that may be effective in treating resistant prostate cancers
Vanderbilt University investigators have discovered a new molecular mechanism that regulates the dynamics of microtubules, which form the cell’s internal skeleton. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery,
For years, scientists have known that regular aspirin use may reduce the risk of cancer. “Studies have shown that aspirin administration for five or more years reduces the incidence of all cancers by 38 percent,” said Pierre Massion, M.D., professor of Medicine and Cancer Biology and director of the Thoracic Program at Vanderbilt-Ingram Cancer Center. […]