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‘Docking stations’ on chromosomes new anti-cancer target

Thursday, March 26th, 2015

Vanderbilt University researchers have discovered a cleft in a chromosome-binding protein that may hold the key to stopping most cancers in their tracks. The protein, WDR5, is a “docking station” for a family of transcription factors called MYC that is overexpressed in the majority of malignancies and which contributes to an estimated 100,000 cancer-related deaths […]

VICC’s Johnson to study cancer survivorship with immune inhibitor drugs

Thursday, March 19th, 2015

Douglas Johnson, M.D., assistant professor of Medicine, has been named a recipient of the National Comprehensive Cancer Network  (NCCN) Foundation Young Investigator Awards. The two-year grant will provide $150,000 in funding for his research on survivorship among cancer patients who receive drugs called immune checkpoint inhibitors. The formal announcement of the grant awardees was made […]

Team blends high-end imaging techniques

Monday, March 16th, 2015

Vanderbilt University researchers have achieved the first “image fusion” of mass spectrometry and microscopy — a technical tour de force that could, among other things, dramatically improve the diagnosis and treatment of cancer. Microscopy can yield high-resolution images of tissues, but “it really doesn’t give you molecular information,” said Richard Caprioli, Ph.D., senior author of […]

Mutations may predict melanoma response to immunotherapies

Thursday, March 12th, 2015

Melanoma patients whose tumors test positive for mutations in the NRAS gene were more likely to benefit from new immunotherapy drugs, according to a new study led by Vanderbilt-Ingram Cancer Center (VICC) investigators. Douglas Johnson, M.D., assistant professor of Medicine, and Christine Lovly, M.D., Ph.D., assistant professor of Medicine and Cancer Biology, are co-first authors […]

‘Cancer: The Emperor of All Maladies’

Wednesday, March 11th, 2015

The Vanderbilt-Ingram Cancer Center, in collaboration with Nashville Public Television, American Cancer Society, and Gilda’s Club, will host a free preview of “Cancer: The Emperor of All Maladies,” panel discussion and moderated Q&A on Wednesday, March 25 at the Vanderbilt University Student Life Center.

Zanic’s journey to lab followed winding path

Monday, March 9th, 2015

It’s roughly 5,000 miles from Croatia to Tennessee as the crow flies. For Marija Zanic, Ph.D., who joined Vanderbilt University’s Department of Cell and Developmental Biology as an assistant professor last August, the journey from her home country took a more circuitous route — from cell biology to theoretical physics and back again. Zanic’s dissertation […]

Grant boosts head and neck lymphedema research

Monday, March 9th, 2015

Vanderbilt University School of Nursing (VUSN) has been awarded a four-year, $2.4 million grant from the National Institutes of Health/National Institute of Dental and Craniofacial Research to establish a valid, clinically useful measurement battery for head and neck lymphedema and fibrosis (LEF). Principal investigator Jie Deng, Ph.D., R.N., developed the proposal because she commonly sees […]

‘Stretched’ cells promote cancer

Thursday, February 26th, 2015

Interactions between tumor cells and other cell types in the surrounding microenvironment (stroma) are crucial for tumor cell growth, survival and metastatic spread. Although tumor cells are known to induce mechanical changes in their microenvironment, few studies have examined the effect of mechanical stimuli on stromal cells such as fibroblasts. Donna Webb, Ph.D., Deyu Li, […]

Antibiotics with anticancer potential

Thursday, February 26th, 2015

The type II topoisomerases – enzymes that manage tangles and supercoils in DNA – exist in all organisms and are important drug targets. Widely prescribed anticancer agents including etoposide and doxorubicin target human type II topoisomerases, and quinolone antibiotics such as ciprofloxacin target bacterial topoisomerases. Clinically relevant quinolones have no activity against human type II […]

Cancer survival improvements vary by age, race

Thursday, February 26th, 2015

Improvements in cancer diagnosis and treatment have led to longer survival for most cancer patients in the United States. However, the improvement in survival was substantially greater among younger patients and those who are white in most of the cancers studied, according to new research by Vanderbilt University investigators. The study was published online recently […]